Chemical Confirmation Services

We are uniquely equipped and qualified to determine the identity, purity and quantity of a chemical in solution from a single micro-volume sample by HPLC-DAD/ELSD/CLND/MS, without an analytical standard of the chemical.   Our expert analytical scientists will perform analysis of your chemical samples (under the applicable regulations), help you anticipate scientific or regulatory challenges, offer strategic solutions to enable you to make critical strategic decisions, and will report your results in an appropriate format.

We have confirmed more than 500,000 chemical solutions (including pharmaceuticals and potential environmental hazards) using this technique, which is particularly helpful in confirming the composition of chemical liquid stores (libraries).


Identity

Using High Performance Liquid Chromatography with Electrospray Ionisation Mass Spectrometry (HPLC-ESI/MS), the retention time (a measure of hydrophobicity) and mass spectra (positive and negative ionization) are evaluated for consistency with the proposed chemical structure of the Compound of Interest (COI).

Quantity

The quantity (i.e., concentration of the COI in the solution) is measured by the appropriate detector, either Chemiluminescent Nitrogen Detector (CLND) for nitrogen containing compounds else Evaporative Light Scattering Detector (ELSD).

Purity

The purity of the COI is determined as an amalgamation of peak area percentage from the Diode Array UV Detector (DAD), the CLND and the ELSD.

Compliance (QMP)

This work is currently performed under an environmental Quality Management Plan (QMP).   We’ve been inspected multiple times by EPA with no findings to-date.